IB-Stim® – A New Era for Adult GI Care

Drug-Free Pain Relief for Functional Dyspepsia & Related Nausea Symptoms

What is Functional Dyspepsia?

The Rome IV Criteria, which are widely used clinical guidelines for diagnosing functional gastrointestinal disorders, define functional dyspepsia (FD) as a condition characterized by:

Patients experiencing pain or discomfort in the upper abdomen with one or more of the following symptoms for the last 3 months, with symptom onset at least 6 months before diagnosis, that cannot be explained by another medical condition1:

  • Postprandial fullness (after a meal)
  • Early satiation when eating
  • Epigastric pain or burning not associated with defecation
IB-Stim for Adults - Drug-Free Pain Relief for Functional Dyspepsia & Related Nausea Symptoms
IB-Stim for Adults - Drug-Free Pain Relief for Functional Dyspepsia & Related Nausea Symptoms
IB-Stim® for Functional Abdominal Pain
IB-Stim® for Functional Abdominal Pain

Less Medications. More Science.

IB-Stim® for Functional Abdominal Pain

IB-Stim is a Percutaneous Electrical Nerve Field Stimulator (PENFS) that sends gentle electrical impulses into cranial nerve bundles located in the ear. The stimulation targets brain areas that process pain including the amygdala and vagus nerve. This helps reduce functional abdominal pain in functional dyspepsia and related nausea symptoms.

IB-Stim is a five-day (120 hours per week) treatment, one device per week for four consecutive weeks.

IFU available at: https://www.ibstim.com/ifu

The Science Behind PENFS

Targeting the amygdala, vagus nerve & brain connectivity

  • Access: IB-Stim enables direct access to the central nervous system (CNS) through peripheral and cranial nerves.
  • Stimulate: PENFS decreased spontaneous firing of amygdala neurons by 65% in a peer-reviewed, pre-clinical study published in Neuroscience (2017)2. PENFS has been shown to restore vagal efficiency in patients with functional abdominal pain and related nausea symptoms in a peer-reviewed clinical study published in Neurogastroenterology & Motility (2025)3.
  • Change: This stimulation changes the brain pathways and connectivity that interpret chronic abdominal pain4.

PENFS has extensively demonstrated safety and clinical efficacy for disorders of the gut-brain interaction (DGBI). Click to view more peer-reviewed publications: https://ibstim.com/current-publications

The Science Behind PENFS
The Science Behind PENFS

Citations

*Please note, the research being described may include information about technology and intended uses of that technology which have not been reviewed or approved/cleared by the U.S. FDA, and is being provided for informational purposes only.

  1. Drossman DA, Hasler WL. Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology. 2016 May;150(6):1257-61. doi: 10.1053/j.gastro.2016.03.035. PMID: 27147121.
  2. Babygirija R, et. al. Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats. Neuroscience. 2017 Jul 25;356:11-21. doi: 10.1016/j.neuroscience.2017.05.012. Epub 2017 May 17. PMID: 28526575.
  3. Kolacz J, et. al. Cardiac Vagal Efficiency Is Enhanced by Percutaneous Auricular Neurostimulation in Adolescents With Nausea: Moderation by Antidepressant Drug Exposure. Neurogastroenterol Motil. 2025 May;37(5):e15007. doi: 10.1111/nmo.15007. Epub 2025 Jan 30. PMID: 39888101; PMCID: PMC11996051.
  4. Woodbury A, et. al. Feasibility of Auricular Field Stimulation in Fibromyalgia: Evaluation by Functional Magnetic Resonance Imaging, Randomized Trial. Pain Med. 2021 Mar 18;22(3):715-726. doi: 10.1093/pm/pnaa317. PMID: 33164085; PMCID: PMC7971465.

Neuromodulation Therapies for Chronic and Debilitating Conditions

Neuromodulation Therapies for Chronic and Debilitating Conditions

Targeted therapies for patients suffering from disorders of the gut-brain interaction (DGBI): functional abdominal pain associated with irritable bowel syndrome, functional dyspepsia (FD), and FD-related nausea symptoms.